Potential New Targets For Antidepressant Medications

�The news about antidepressant drug medications over the past several years has been mixed. The bad news from tumid multicenter studies such as STAR*D is that current antidepressant medications are in force, but non as effective as one might hope. Thus, in that respect is a significant pauperization for new treatment mechanisms for depression. On that front, thither has been mixed news as comfortably. One of the most exciting new drugs to reach human clinical trials, one that blocks the corticotrophin cathartic factor-1 (CRF1) receptor, did not process in a large clinical trial sponsored by Pfizer Pharmaceuticals. Is it meter to give up CRF1 antagonists as antidepressants or should we revisit these agents from a new linear perspective? It is in this context that a new paper by Alexandre Surget and colleagues, scheduled for publication in the August 15th issue of Biological Psychiatry, is particularly interesting.


Through prior work, it has been shown that the power to blow the stress-related disruption of hippocampal neurogenesis, the ability of the brain to make modern nerve cells in adulthood, was important to the actions of our available antidepressant medications. In this new study, the researchers affirm the prior findings, but suggest that deuce experimental approaches to the treatment of depression, block off of the CRF1 sensory receptor or the vasopressin-1B (V1B) receptor, retain their efficacy in reversing the shock of stress on demeanour even when neurogenesis is disrupted. Catherine Belzung, Ph.D., corresponding author on this article, further explains that "we now report evidence that restoration of the functioning of the stress axis may be the key to how these new antidepressant approaches might work."


How can unrivalled reconcile these interesting enquiry findings in animals with the lack of antidepressant drug efficacy of a CRF1 receptor antagonist in the Pfizer study? Is this approach just ineffective in humans or might at that place be subgroups of patients who power be more likely to respond to a CRF1 antagonist? The Surget et al. data raise the possibility that CRF1 sense organ antagonists might be effective in treating stress-related behavioral disturbances regular in a context where other antidepressants do non work, perhaps due to disruption of neurogenesis. John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, comments: "These findings loan weight to the hope that CRF1 antagonists might play a role in the handling of antidepressant-resistant symptoms of depression or posttraumatic accent disorder. If so, CRF1 antagonists could fulfill an important unmet need." He adds that "we do not pauperism another Prozac, but we urgently need to find ways to help the large number of patients who fail to respond adequately to our available treatments."

Elsevier


View drug data on Prozac Weekly.



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Download Steelheart mp3

Artist: Steelheart: mp3 download    Genre(s):  Rock: Hard-Rock     Discography:      Tangled In Reins    Year: 1992    Tracks: 10 Hailing from Norwalk, CT, Steelheart was one of the very last pilus metallic element bands to scotch a attain with a power ballad, plainly before Nirvana and their like annihilated the genre completely. Originally called Red Alert, the quartet (which included vocalizer Michael Matijevic, guitarist Chris Risola, bassist James Ward, and drummer Frank Dicostanzo) exhausted most of the 10 playing the tri-state area and honing their pretend. After long clip of difficult work, the band in conclusion secured a phonograph record deal with MCA, and changed their nominate to Steelheart. 1991 saw the release of their self-titled debut, which spawned the strike big businessman lay, "Never Let You Go," which reached speech sound number 14 on the Billboard singles chart. The dance band rapidly began work on their sophomore effort, Tangled in Reins, which was released a year later on. But disaster was lurking simply just about the corner -- at a Halloween picture orifice for Slaughter at McNichol's Arena in Denver, CO, Matijevic was smitten in the oral sex by a firing truss, knock him to the ground face showtime, and he free burning serious head injuries. Forced to take a get around for their vocaliser to recoup, the musical clime had changed dramatically, resulting in the band occupational group it a day shortly thereafter. But by 2000, the mathematical group had reunited and issued a third gear record album, titled Wait.

Yung Burg Busted For Gun And Weed Possession

Chicago rapper Yung Berg was reportedly arrested in New York yesterday morning (August 9) on gun and marijuana charges.

According to TMZ, a limousine driver filed a complaint with police claiming he got into a dispute with Yung Berg and his entourage.

The police investigating the complaint would arrest and charge Yung Berg along with four of his associates.

Yung Berg was charged with criminal possession of a weapon, criminal possession of marijuana and menacing.

The rapper is currently on a promotional tour in support of his latest album titled Look What You Made Do.� The set hits stores on Tuesday (August 12).

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Jon Secada

   
Artist: Jon Secada

   Genre(s): 
Dance
   Other
   R&B: Soul
   Vocal
   Pop
   Latin
   

---

Discography:


   
 Window To My Heart (George Acosta Remixes) CDM

   Year: 2006   
Tracks: 5


   
 Same Dream

   Year: 2006   
Tracks: 13


   
 The Greatest Hits

   Year: 1999   
Tracks: 13


   
 Grandes Exitos

   Year: 1999   
Tracks: 12


   
 Heart Soul and A Voice

   Year: 1994   
Tracks: 13


   
 Otro Dia Mas Sin Verte

   Year: 1992   
Tracks: 10


   
 Amanecer

   Year:    
Tracks: 11

---

Jon Secada (he legally changed his first diagnose from Juan in 1990) immigrated to the U.S. at the historic period of clubhouse in 1971, subsidence in Miami where his parents opened a coffee shop. He earned both a B.A. and a M.A. in jazz vocal functioning at the University of Miami. Becoming byzantine with Gloria Estefan's career, he co-wrote sestet songs on her multi-platinum 1991 album Into the Light, among them the number one hit "Coming out of the Dark," and american ginseng succour vocals on her subsequent tour. Then he signed to SBK Records and launched his own vocation with a self-titled debut record in 1992. With only peerless album, he became 1 of the biggest adult modern-day originative person of the '90s, marketing all over sise zillion albums planetary. His smooth meld of R&B, pop, and Latin music appealed to a number of different audiences. As well as seemly a vast English-language pop asterisk, he became one of the hottest Latin artists recording in the '90s; Otro Día Más Sin Verte (a Spanish-language adaptation of Jon Secada) was Billboard's number one Latin album in 1992 and won a Grammy for Best Latin Pop Album. His arcsecond gear English-language album, Heart, Soul & a Voice (1994), sold over a jillion copies. Amor (1995), his second base Spanish-language album, won him another Grammy. Secada (1997) was a commercial disappointment, and the vocalizer touched to Sony Music's Epic Records where his offset duties including piece of writing songs for labelmates Ricky Martin and Jennifer Lopez. In July of 2000, Epic released his label debut, Wagerer Part of Me.

Robbie Rivera Feat Justine Suissa

   
Artist: Robbie Rivera Feat Justine Suissa

   Genre(s): 
House
   

---

Discography:


   
 Float Away Incl Gabriel And Dresden Re-Edit

   Year: 2006   
Tracks: 8

---

 

Heat it up with desert babes

WITH the sun going in and the girls covering up again - we've got some
sizzling snaps to brighten up your day.
BOB SINCLAR presenting FIREBALL have given us a look at their
new sexy video, starring a bunch of plain janes who turn into super hotties
at a desert boot camp.
For more fab snaps, click on our slideshow below:
What I Want - already a massive hit across Europe - will be released on
Hard2Beat, the same prestigious label as BASSHUNTER and SEPTEMBER.
And what better way to kick off the UK release than with a play from PETE
TONG at the beginning of his legendary Radio 1 Miami pool party.

And if you think he sounds familiar, Parisian DJ Chris Lefriant’s alter-ego
Bob Sinclar also enjoyed UK chart success with I Feel For You and Love
Generation.
What I Want is released digitally on July 28 and hits the shops from August
4

Pete Doherty - Winemouse Baffles Fans

Pete Doherty and Amy Winehouse left fans scratching their heads after posting a video showing them playing with baby mice.

The pair, both of whom have struggled with drug problems in the past two years, are seen in a blue-lit room showing a box containing around 30 mice to the camera.

They then pick up two or three of the mice and use them, it seems, as an outlet for their somewhat dazed and confused emotions.

"This is a dawning of a new mouse life," the pair sing, before Doherty treats the viewer to another dose of his acerbic wit: "Look at the wiggly wibble. Wiggly wibble!"

Later in the video he says one mouse "looks like [Razorlight frontman] Johnny Borrell when he's just got out of the bath".

Winehouse's own ramblings are much more personal.

"This one's got a message for Blake. Blake, please don't divorce mummy. She loves you loads," she says.

"If you divorce me, you love her. I'm only a day old. I don't know what I'm doing, but I know what love is."

"Awww," Doherty responds.

The two-minute clip appeared yesterday on video-posting website YouTube, where fans largely gave a negative response to the news.

Some were impressed by the "cute" mice but others said they were worried by the babies being handled by Winehouse and Doherty's undeniably unwashed fingers.

"Don't mice reject their children if humans handle them too much?" asked KateKennedy729, one of several raising the same concern.

Others appealed to the pair to recover from their drug problems.

Flobolobo pointed out that a "mumbling ramshackle haze of existence is hardly 'living the good life'", while re1d described the video as "so cute, like watching a car crash".

"I don't understand how you guys can even begin to think they're off drugs," commented zammit, while lheep's response was: "It's too heartbreaking to witness… you're just two kids in the end."


18/05/2008 09:37:32

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Jaime Pressly - Pressly Sued Over Fashion Line

A fashion designer is suing actress JAIME PRESSLY over claims she was unfairly axed from her fashion line.

Tami Smith claims the My Name Is Earl star hired her to design pieces for her J'aime fashion line.

In a lawsuit filed at Los Angeles County Superior Court on Monday (02June08), Smith claims she made a deal with Pressly to "represent and market" her line and spent "substantial devotion of time and effort" doing so, only to have her commissions shelved by Jaime and her company.

She is suing the star for $150,000 (GBP75,000) in fees, reports TMZ.com.

A spokesman for Pressly was unavailable for comment.

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Kidman not so LA confidential

Nicole Kidman is said to have posed nude in a photo shoot that will show off her pregnant belly.

My Chemical Romance - My Chemical Romance Fans To March On London

Fans of goth rockers MY CHEMICAL ROMANCE are to march on London on 31 May (08) to protest the group's treatment by the British media.

Newspapers and magazines in the U.K. have taken aim at the band for their dark, moody music and lyrics, which have turned them into superstars among 'emo' youths.

And now their fans are planning an uprising on later this month (31May08) to show their displeasure at reports about their heroes.

Hundreds of My Chemical Romance fans are expected to march from London's Hyde Park to the offices of Britain's the Daily Mail newspaper.

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Meaney to star in football biopic

Colm Meaney will star in 'The Damned United', a biopic of legendary English soccer coach Brian Clough
According to Variety the €6.5 million film will be directed by Tom Hooper from a script by Peter Morgan.
The biopic will tell the dramatic story of controversial football manager Clough and his turbulent 44-day reign as the coach of Leeds United in 1974.
Michael Sheen, who played Tony Blair in 'The Queen', the previous collaboration between Morgan and Harries, is set to play Clough.
Tim Spall will take the role of his sidekick Peter Taylor, Jim Broadbent will be the chairman of Derby County and Meaney will play rival coach Don Revie and.
'The Damned United' is due to begin shooting on 25 May.
Meaney is also working on an American version of the hit series 'Life on Mars', in which he'll star as Detective Gene Hunt. To see our interview with Meaney click here.

Faith and The Muse

   
Artist: Faith and The Muse

   Genre(s): 
Rock: Gothic
   

---

Discography:


   
 Evidence Of Heaven

   Year: 2001   
Tracks: 14

---

 





'American Idol' Producer Explains Ban On David Archuleta's Dad: 'Let's Take Some Pressure Away Here'

LiveDaily Song of the Day: Eric Avery - "All Remote and No Control"

Today's Song of the Day is by Eric Avery [ tickets ]. The featured cut is "All Remote and No Control," which appears on the former Jane's Addiction bassist's forthcoming solo debut, "Help Wanted."


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Cruise Fights To Silence Baby Boutique Owners

Tom Cruise has slapped the owners of a top Los Angeles baby boutique with a cease and desist letter, accusing them of going public with purchases he and wife Katie Holmes have made without their permission. The movie star's legal team has fired off documents to the bosses of Petit Tresor, warning them to stop talking to the media about private Cruise family matters. According to the documents, obtained by TMZ.com, Cruise was particularly upset when store bosses allegedly leaked false information suggesting the actors have spent more than $350,000 on wardrobe items for their daughter Suri in the two years since her birth. The lawyers insist no one at the store should "say anything (whether true or false) about Mr. Cruise and Ms. Holmes' shopping habits."


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Angelina Jolie - Uk Tabloid Publishes Jolie Drug Video

A British tabloid newspaper has published images of a video which allegedly shows ANGELINA JOLIE in a "drugs den" with a woman who is openly smoking heroin.

The actress is shown in video images published in The Sun newspaper looking dishevelled and wide-eyed as she smokes a cigarette and tells the camera of her past drug use.

The video captures the star reportedly saying, "I've done coke, heroin, ecstasy, LSD, everything."

Last month (Apr08), it was reported by America's National Enquirer a videotape of Jolie allegedly smoking and snorting heroin had been offered for sale for $70,000 (GBP35,000).

But in this footage, thought to be taken in the 1990s when she was in her 20s, Jolie does not take drugs, telling the camera, "I gave them up long ago."

However, she allegedly discusses her interest in bizarre sex games, claiming that taking part in sexual activity where people get hurt is "just a cool thing".

Jolie, who has three adopted children, a biological daughter and is expecting twins with actor partner Brad Pitt, has spoken out about her past substance abuse before, once saying, "I hate heroin because I've been fascinated with it. I'm not immune, but I won't do it now, at all."

It is not known if the video referred to in The Sun newspaper is the same video reported as up for sale by the National Enquirer.

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DMX Arrested On Drug And Animal Cruelty Charges

Rapper DMX was arrested on animal cruelty and drug possession charges yesterday.

The superstar had to be forced out of his Arizona home at 3am after barricading himself in his bedroom, cops tell TMZ.com.

He was eventually arrested and charged with seven misdemeanour counts of cruelty. Police took five pit bull puppies into care, and discovered a cache of weapons and drugs - which resulted in further charges.

MTV reports that the arrest stems from a raid on DMX's property in August last year during which police removed 12 pit bulls and a collection of weapons.

Cops discovered the dogs "weren't getting proper food, they weren't getting proper water, and they were tied outside in 115-degree heat".

County Sheriff Joe Arpaio, who is running the investigation, released the

following statement about Friday's arrest, "A guy like this DMX character, with all his money and fame, has no excuse for not providing proper care for his animals. He has a long criminal history and obviously has little or no respect for the law.

"A person's celebrity status does not preclude this office from bringing charges. We are handling this case as we would any other indictment of alleged animal cruelty."

It's the second time DMX - real name Earl Simmons - has been arrested in three days; on Tuesday he was booked for speeding offences, after cops had reviewed footage of him racing at speeds of up to 114 miles per hour back in January.

For those crimes, he faces charges of racing on a highway, reckless driving,

two counts of endangerment, three counts of criminal speed and driving on a suspended license.


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