Potential New Targets For Antidepressant Medications

�The news about antidepressant drug medications over the past several years has been mixed. The bad news from tumid multicenter studies such as STAR*D is that current antidepressant medications are in force, but non as effective as one might hope. Thus, in that respect is a significant pauperization for new treatment mechanisms for depression. On that front, thither has been mixed news as comfortably. One of the most exciting new drugs to reach human clinical trials, one that blocks the corticotrophin cathartic factor-1 (CRF1) receptor, did not process in a large clinical trial sponsored by Pfizer Pharmaceuticals. Is it meter to give up CRF1 antagonists as antidepressants or should we revisit these agents from a new linear perspective? It is in this context that a new paper by Alexandre Surget and colleagues, scheduled for publication in the August 15th issue of Biological Psychiatry, is particularly interesting.


Through prior work, it has been shown that the power to blow the stress-related disruption of hippocampal neurogenesis, the ability of the brain to make modern nerve cells in adulthood, was important to the actions of our available antidepressant medications. In this new study, the researchers affirm the prior findings, but suggest that deuce experimental approaches to the treatment of depression, block off of the CRF1 sensory receptor or the vasopressin-1B (V1B) receptor, retain their efficacy in reversing the shock of stress on demeanour even when neurogenesis is disrupted. Catherine Belzung, Ph.D., corresponding author on this article, further explains that "we now report evidence that restoration of the functioning of the stress axis may be the key to how these new antidepressant approaches might work."


How can unrivalled reconcile these interesting enquiry findings in animals with the lack of antidepressant drug efficacy of a CRF1 receptor antagonist in the Pfizer study? Is this approach just ineffective in humans or might at that place be subgroups of patients who power be more likely to respond to a CRF1 antagonist? The Surget et al. data raise the possibility that CRF1 sense organ antagonists might be effective in treating stress-related behavioral disturbances regular in a context where other antidepressants do non work, perhaps due to disruption of neurogenesis. John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, comments: "These findings loan weight to the hope that CRF1 antagonists might play a role in the handling of antidepressant-resistant symptoms of depression or posttraumatic accent disorder. If so, CRF1 antagonists could fulfill an important unmet need." He adds that "we do not pauperism another Prozac, but we urgently need to find ways to help the large number of patients who fail to respond adequately to our available treatments."

Elsevier


View drug data on Prozac Weekly.



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Download Steelheart mp3

Artist: Steelheart: mp3 download    Genre(s):  Rock: Hard-Rock     Discography:      Tangled In Reins    Year: 1992    Tracks: 10 Hailing from Norwalk, CT, Steelheart was one of the very last pilus metallic element bands to scotch a attain with a power ballad, plainly before Nirvana and their like annihilated the genre completely. Originally called Red Alert, the quartet (which included vocalizer Michael Matijevic, guitarist Chris Risola, bassist James Ward, and drummer Frank Dicostanzo) exhausted most of the 10 playing the tri-state area and honing their pretend. After long clip of difficult work, the band in conclusion secured a phonograph record deal with MCA, and changed their nominate to Steelheart. 1991 saw the release of their self-titled debut, which spawned the strike big businessman lay, "Never Let You Go," which reached speech sound number 14 on the Billboard singles chart. The dance band rapidly began work on their sophomore effort, Tangled in Reins, which was released a year later on. But disaster was lurking simply just about the corner -- at a Halloween picture orifice for Slaughter at McNichol's Arena in Denver, CO, Matijevic was smitten in the oral sex by a firing truss, knock him to the ground face showtime, and he free burning serious head injuries. Forced to take a get around for their vocaliser to recoup, the musical clime had changed dramatically, resulting in the band occupational group it a day shortly thereafter. But by 2000, the mathematical group had reunited and issued a third gear record album, titled Wait.

Yung Burg Busted For Gun And Weed Possession

Chicago rapper Yung Berg was reportedly arrested in New York yesterday morning (August 9) on gun and marijuana charges.

According to TMZ, a limousine driver filed a complaint with police claiming he got into a dispute with Yung Berg and his entourage.

The police investigating the complaint would arrest and charge Yung Berg along with four of his associates.

Yung Berg was charged with criminal possession of a weapon, criminal possession of marijuana and menacing.

The rapper is currently on a promotional tour in support of his latest album titled Look What You Made Do.� The set hits stores on Tuesday (August 12).

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Jon Secada

   
Artist: Jon Secada

   Genre(s): 
Dance
   Other
   R&B: Soul
   Vocal
   Pop
   Latin
   

---

Discography:


   
 Window To My Heart (George Acosta Remixes) CDM

   Year: 2006   
Tracks: 5


   
 Same Dream

   Year: 2006   
Tracks: 13


   
 The Greatest Hits

   Year: 1999   
Tracks: 13


   
 Grandes Exitos

   Year: 1999   
Tracks: 12


   
 Heart Soul and A Voice

   Year: 1994   
Tracks: 13


   
 Otro Dia Mas Sin Verte

   Year: 1992   
Tracks: 10


   
 Amanecer

   Year:    
Tracks: 11

---

Jon Secada (he legally changed his first diagnose from Juan in 1990) immigrated to the U.S. at the historic period of clubhouse in 1971, subsidence in Miami where his parents opened a coffee shop. He earned both a B.A. and a M.A. in jazz vocal functioning at the University of Miami. Becoming byzantine with Gloria Estefan's career, he co-wrote sestet songs on her multi-platinum 1991 album Into the Light, among them the number one hit "Coming out of the Dark," and american ginseng succour vocals on her subsequent tour. Then he signed to SBK Records and launched his own vocation with a self-titled debut record in 1992. With only peerless album, he became 1 of the biggest adult modern-day originative person of the '90s, marketing all over sise zillion albums planetary. His smooth meld of R&B, pop, and Latin music appealed to a number of different audiences. As well as seemly a vast English-language pop asterisk, he became one of the hottest Latin artists recording in the '90s; Otro Día Más Sin Verte (a Spanish-language adaptation of Jon Secada) was Billboard's number one Latin album in 1992 and won a Grammy for Best Latin Pop Album. His arcsecond gear English-language album, Heart, Soul & a Voice (1994), sold over a jillion copies. Amor (1995), his second base Spanish-language album, won him another Grammy. Secada (1997) was a commercial disappointment, and the vocalizer touched to Sony Music's Epic Records where his offset duties including piece of writing songs for labelmates Ricky Martin and Jennifer Lopez. In July of 2000, Epic released his label debut, Wagerer Part of Me.

Robbie Rivera Feat Justine Suissa

   
Artist: Robbie Rivera Feat Justine Suissa

   Genre(s): 
House
   

---

Discography:


   
 Float Away Incl Gabriel And Dresden Re-Edit

   Year: 2006   
Tracks: 8

---

 

Heat it up with desert babes

WITH the sun going in and the girls covering up again - we've got some
sizzling snaps to brighten up your day.
BOB SINCLAR presenting FIREBALL have given us a look at their
new sexy video, starring a bunch of plain janes who turn into super hotties
at a desert boot camp.
For more fab snaps, click on our slideshow below:
What I Want - already a massive hit across Europe - will be released on
Hard2Beat, the same prestigious label as BASSHUNTER and SEPTEMBER.
And what better way to kick off the UK release than with a play from PETE
TONG at the beginning of his legendary Radio 1 Miami pool party.

And if you think he sounds familiar, Parisian DJ Chris Lefriant’s alter-ego
Bob Sinclar also enjoyed UK chart success with I Feel For You and Love
Generation.
What I Want is released digitally on July 28 and hits the shops from August
4

Pete Doherty - Winemouse Baffles Fans

Pete Doherty and Amy Winehouse left fans scratching their heads after posting a video showing them playing with baby mice.

The pair, both of whom have struggled with drug problems in the past two years, are seen in a blue-lit room showing a box containing around 30 mice to the camera.

They then pick up two or three of the mice and use them, it seems, as an outlet for their somewhat dazed and confused emotions.

"This is a dawning of a new mouse life," the pair sing, before Doherty treats the viewer to another dose of his acerbic wit: "Look at the wiggly wibble. Wiggly wibble!"

Later in the video he says one mouse "looks like [Razorlight frontman] Johnny Borrell when he's just got out of the bath".

Winehouse's own ramblings are much more personal.

"This one's got a message for Blake. Blake, please don't divorce mummy. She loves you loads," she says.

"If you divorce me, you love her. I'm only a day old. I don't know what I'm doing, but I know what love is."

"Awww," Doherty responds.

The two-minute clip appeared yesterday on video-posting website YouTube, where fans largely gave a negative response to the news.

Some were impressed by the "cute" mice but others said they were worried by the babies being handled by Winehouse and Doherty's undeniably unwashed fingers.

"Don't mice reject their children if humans handle them too much?" asked KateKennedy729, one of several raising the same concern.

Others appealed to the pair to recover from their drug problems.

Flobolobo pointed out that a "mumbling ramshackle haze of existence is hardly 'living the good life'", while re1d described the video as "so cute, like watching a car crash".

"I don't understand how you guys can even begin to think they're off drugs," commented zammit, while lheep's response was: "It's too heartbreaking to witness… you're just two kids in the end."


18/05/2008 09:37:32

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